Equine veterinarian Dr. Don Baker says he taps into natural resources from some of the same countries once trod by Marco Polo to develop System Saver™, an effective, safe, plant-based alternative to corticosteroids, non-steroidal anti-inflammatories, and immunosuppressants for addressing inflammation and degenerative horse disease.
All Natural System Saver offers hope for inflammatory and degenerative conditions via time-honored ingredients: frankincense (boswellia serrata), mandarin and other orange peels (citrus reticulata), turmeric (curcuma longa), and green tea (camelia sinensis).
Frankincense (boswellia serrata) trees grow in India, Northern Africa and the Middle East. When sections of its bark are peeled away, it yields a gummy resin whose extracts have been used for centuries in Ayurvedic medicine as an anti-arthritic, astringent, stimulant, expectorant and antiseptic.
Compounds in organic acids (beta-boswellic acid, alpha-keto bosellic acid and acetyl-11-keto-beta-boswellic acid) have been found to inhibit pro-inflammatory and cell-signaling pathway chemicals and cytokines involved in chemotaxis, increase vascular permeability, and brochoconstriction.
They also inhibit matrix metalloproteinases (MMPs) involved in cartilage destruction, tumor invasion and metastasis. Unlike traditional anti-inflammatory drugs, whose side effects disrupt glycosaminoglycan synthesis and accelerate articular cartilage damage in arthritic conditions, frankincense extract reduces degradation of cartilage. Frankincense extract has demonstrated efficacy in asthma, chronic bronchitis, arthritis, rheumatoid arthritis, chronic colitis, ulcerative colitis, Crohn’s disease and chemo-prevention (pre-cancer).
Mandarin orange peel (citrus reticulata) and other orange peels (C.aurantium-bitter orange, C.sinensis-sweet orange) are sources of bioflavonoids. Orange peel extract has been used in Chinese medicine: Chen pi (Chinese mandarin orange peel) is traditionally used to move stagnant Chi (energy that flows through the meridians). Other uses include relief of gas, indigestion, heartburn, catarrh, chest congestion, and as an anti-inflammatory, carminative, cholagogue and tonic.
Recent studies on polymethoxylated flavone components in orange peel have demonstrated preventive and therapeutic potential relevant to arthritis, inhibition of enzymatic cartilage destruction, asthma and COPD, inflammatory conditions (acute and chronic), hyperlipidemia (lowers serum lipids), high cholesterol and LDL, hyperglycemia (glucose homeostasis), insulin resistance, heart disease, varicose veins, capillary permeability, and hepatitis C.
“Flavonoids have been referred to as ‘nature’s biological response modifiers’ because of strong experimental evidence of their ability to modify the body’s reaction to allergens, viruses and carcinogens, microbes and inflammation,” Dr. Baker says.
“Flavonoids have been shown to strongly influence gene expression and cell signaling pathways involved in cancer and heart disease. They increase the activity of nitric oxide synthase, which has the effect of keeping blood vessels healthy and relaxed, thereby preventing inflammation and lowering blood pressure, both relevant to heart disease. Like curcuminoids, flavonoids have MMP inhibitory activity which helps relieve chronic inflammation and inhibit cartilage destruction and tumor invasion (metastasis).”
Turmeric (curcuma longa) and other curcuma species have been used for centuries in Asia and India as spices, preservatives, and therapeutic agents within Ayurevedic and Chinese medicine. Bioactive constituents (curcuminoids) have demonstrated anti-inflammatory, anti-oxidant, anti-viral, chemo-preventive and anti-cancer activities, as well as molecular biological action such as MMP inhibitory activity, inhibition of arachadonic acid metabolism, and inhibition of interleukin, TNF and cyclooxygenase2 activity.
Curcumin’s anti-inflammatory activity has been demonstrated qw equivalent to that of Butazolidin (a prescription medication). If curcumin is combined with a traditional non-steroidal anti-inflammatory drug (NSAID), it enhances the effect as much as ten-fold. It has demonstrated efficacy in relieving symptoms of arthritis as well as inhibiting the joint-destructive activity of MMPs responsible for degradation of cartilage and tumor metastasis. Matrix-metalloproteinases (MMPs) help perpetuate the cycle behind many chronic inflammatory diseases.
“Curcumin,” Dr. Baker says, “has demonstrated chemo-preventive activity against colon, duodenal, fore-stomach, mammary, leukemic, pancreatic, oral, and skin cancers, has been shown to support cardiovascular health by lowering serum lipids and total cholesterol while promoting an increase in HDL (good cholesterol), and has been found efficacious in suppressing symptoms of Type II diabetes, multiple sclerosis and Alzheimer’s.”
Green tea (camellia sinensis) comes from an Asian evergreen shrub whose leaves provide green and black tea as a beverage and therapeutic herb. In traditional Chinese and Indian medicine, practitioners use green tea as a stimulant, diuretic (to promote urine excretion), astringent (to control bleeding and help heal wounds), and improve heart health. Other uses include treating flatulence (gas), regulating body temperature and blood sugar, promoting digestion, and improving mental processes.
Green tea has been the subject of scientific research on high anti-oxidant activity to neutralize free radicals that damage cells and genetic material (DNA & RNA) and are involved in the aging process. Green tea’s anti-oxidant benefits are the result of polyphenols — catechins and gallocatechins — that possess anti-inflammatory, anti-cytokine and MMP inhibitory activity. These activities (inflammation, free radical damage, increased cytokine and MMP activity) are instrumental for an array of conditions including: heart disease, atherosclerosis, arthritis, cancer, cartilage destruction, asthma, colitis (IBD/Crohn’s), insulin resistance, diabetes and chronic inflammatory diseases (rheumatoid arthritis, multiple sclerosis, pulmonary fibrosis). Studies have shown catechins and gallocatechins to be beneficial and green tea has been shown to reduce elevated cholesterol levels while increasing HDL (good cholesterol).
“Since dietary supplements are not drugs and therefore are not regulated by the FDA, we are required to add that these statements have not been evaluated by the FDA, and this product is not intended to diagnose, treat, cure or prevent any disease,” Dr. Baker says.
But the testimonials of animal care professionals, like “Martha Stewart’s vet,” Marty Goldstein, DVM, and holistic veterinarian Dr. Regina Schwabe, support one fact: You don’t have to search the world over like Marco Polo to find a natural alternative for the animals you love.
About them: System Saver™ is an herbal dietary supplement developed by a veterinarian that regulates over-active immune, inflammatory and degenerative processes. It provides relief from the symptoms associated with inflammation including pain, swelling and loss of function. System Saver’s unique dual action mechanism inhibits chronic inflammation, as well as tissue degeneration. Its proprietary blend contains a broad spectrum of metalloproteinase inhibitors, produced from standardized plant extracts of Citrus reticulata, Frankincense, Curcuma longa, and Camelia sinensis.
Learn more about All Natural System Saver by Biotrope, Inc., by visiting www.systemsaver.net, or calling toll-free, (888) 581-1220.